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KMID : 0043320060290070535
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Archives of Pharmacal Research
2006 Volume.29 No. 7 p.535 ~ p.540
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Antibacterial, Antifungal and Anticonvulsant Evaluation of Novel Newly Synthesized 1-[2-(1H-Tetrazol-5-yl)ethyl]-1H-benzo[d][1, 2,3]triazoles
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Rajasekaran Aiyalu
Murugesan Sankaranarayanan
AnandaRajagopal Kalasalingam
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Abstract
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Several novel 1-[2-(1H-tetrazol-5-yl) ethyl]-1H-benzo[d][1,2,3]triazoles (3a-h) have been synthesized by the condensation of 1-[2-(1H-tetrazol-5-yl)-ethyl]-1H-benzotriazole (2) and appropriate acid chlorides. 1-[2-(1H-tetrazol-5-yl)-ethyl]-1H-benzotriazole (2) was synthesized by reacting 3-(1H-benzo[d][1,2,3]triazol-1-yl)propanenitrile with sodium azide and ammonium chloride in the presence of dimethylformamide. The synthesized compounds were characterized by IR and PMR analysis. The titled compounds were evaluated for their in vitro antibacterial and antifungal activity by the cup plate method and anticonvulsant activity evaluated by the maximal electroshock induced convulsion method in mice. All synthesized compounds exhibited moderate antibacterial activity against Bacillus subtilis and moderate antifungal activity against Candida albicans. Compounds 5-(2-(1 H-benzo[d][1,2,3]triazo-1-yl)ethyl)-1H-tetrazol- 1-yl)(4-aminophenyl)methanone 3d and 5-(2-(1 H-benzo[d][1,2,3]triazo-1-yl)ethyl)-1H-tetrazol- 1-yl)(2-aminophenyl)methanone 3e elicited excellent anticonvulsant activity.
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KEYWORD
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Synthesis, 1-[2-(1H-tetrazol-5-yl)ethyl]-1H-benzo[d][1, 2, 3]triazoles, Antibacterial activity, Antifungal activity, Anticonvulsant activity
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